| Date |
Apr 20, 2016 |
| Speaker |
Prof. Jinn-Moon Yang, Department of Biological Science and Technology,
Institute of Bioinformatics & Systems Biology,
National Chiao Tung University
|
| Title |
NetPharmalogs for drug discovery and applications
|
| Abstract |
The concept of "one-disease, one-target, one-drug" is the mainstream for
drug discovery strategy in the past decades. Some complex diseases
(e.g., cancers) were typically caused by multiple genes and pathways.
The drugs derived by the single-target strategy may become ineffective
for complex diseases and may lead to drug resistance. We have
accumulated extensive experience in drug discovery (GEMDOCK and
site-moiety map) and systems biology. In this talk, I will introduce a
concept “NetPharmalogs” to discover new drugs that inhibit multiple
targets in the same pathway or in multiple pathways to increase
therapeutic potency and decrease probability of drug resistance for
complex diseases. The core idea of the NetPharmalogs is the molecular
interaction family, including protein-drug and protein-protein families,
for exploring interacting and pathway mechanisms and therapeutic targets
which are essential for complex diseases.
For a drug-protein-pathway-disease network, Netpharmalogs is to identify
the targeting proteins, which share similar physical-chemical properties
and shapes of their binding sites, are often inhibited by the same
(similar) inhibitor. We have successfully utilized Netpharmalogs and
computational systems biology to explore the binding and pathway
mechanisms for drug design and complex diseases. In this talk, I will
describe several application cases: 1) Exploring nicotine-induced cancer
mechanisms regulated by nicotinic acetylcholine receptor subunit
alpha-9; 2) Studying the compound-protein-pathway-disease networks for
multiple ingredients of a plant. 3) Discovering new mechanisms and new
type inhibitors that are high selectivity and anti-drug resistance for
protein kinases.
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