ゲノム情報科学研究教育機構  アブストラクト
Date January 11, 2012
Speaker Professor Von-Wun Soo, Department of Computer Science and Institute of Information Systems and Applications, National Tsing Hua University, Taiwan
Title Identify Drug Co-target to Fight Drug Resistance Based on a Random Walk Model
Abstract We propose a heuristic search algorithm in order to extract drug response pathways from protein-protein interaction networks and microarray data and used a random walk model to identify the potential co-target for effective antibacterial drugs. In particular, we chose one of the killer infectious diseases, Mycobacterium tuberculosis (Mtb) as our test bed. Our approach applied A* heuristic search algorithm in order to extract pathways and networks from its protein-protein interaction database for the drug resistance and then a random walk is conducted over the networks to further identify for effective antibacterial drugs. Our results are consistent with the recent experimental results.
「セミナー」に戻る      
 ホーム