ゲノム情報科学研究教育機構  アブストラクト
Date July 16, 2009
Speaker Dr. Zhiping Liu, Chinese Academy of Sciences, Osaka Sangyo University, China
Title Dynamically dysfunctional protein interactions in the development of Alzheimer's disease
Abstract Alzheimer's disease usually causes dementia in the old people and the symptom progression of the disease phenotype displays certain patterns. In this study, we will identify the dynamics of disease progression based on its biomolecular network. We develop a novel computational method to integrate an ensemble protein network and the gene expression data.
Specifically, we construct the dysfunctional dynamical pathways which present particular characteristics at different disease stages. Based on the network-based method, we reveal that the pathways of protein interactions tend to be more complicated during the development of disease. Also we find that the disease proteins performing important functions are always located in the cooperations of the identified pathways. These results demonstrate that the network-based analysis can provide knowledge and evidences on the dynamics and pathological pathways of the complex Alzheimer’s disease.
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